Endothelial Dysfunction/Atherosclerosis Acceleration
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This article will explore the risk-taking
behavior of adolescents engaging in vaping;
the effects of vaping and the indiscriminate
use of nicotine products on the young; and
strategies that healthcare providers can use
to collaborate with patients and families to
reduce their risk of harm from this emerging
public health epidemic.
Background The first e-cigarette was conceptualized
and patented in 1965 by Herbert Gilbert as
a safe and harmless modality to smoking
cigarettes.3,4 In 2003, an electronic atomiz-
er version was patented by Ruyan Technol-
ogy in China, marketed to the United States
in 2007, and touted as a healthier alternative
to smoking conventional cigarettes.3 Since
the emergence of Ruyan’s first-generation
e-cigarette, novel models have emerged in
design, engineering, and nicotine delivery
methods resulting in second-, third-, and
fourth-generation ENDS delivery devices.4
What the vaping culture entails Vaping refers to the vaporization of
substances (nicotine, flavorings, can-
nabis, or other substances in popu-
larity) wherein oil, liquid, or plant
material is heated to a temperature
resulting in the release of aerosol-
ized water vapor and active ingredi-
ents (nicotine, cannabis) delivered
via inhaled aerosol.3-5 Tremendous
controversy has arisen surrounding
potential harm reduction or risks as-
sociated with e-cigarettes/vaping in
young persons.3
Nicotine, a highly addictive sub-
stance in any form, is commonly
vaped.3,4 Health effects of nicotine in-
clude hemodynamic effects second-
ary to catecholamines (eg, increase
in heart rate and blood pressure; va-
soconstriction of arteries and vessels;
endothelial dysfunction; atheroscle-
rosis acceleration).3
During adoles-
cence while the brain is developing,
nicotine can result in addiction and
harmful consequences such as be-
havioral and cognitive impairments,
memory issues, inattention, and ex-
ecutive function impairments.4,6
Harmful effects have been found
from e-cigarette aerosol and addi-
tives.4 Brief exposure to propylene
glycol aerosol has been reported to
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