Inflammatory bowel disease (IBD) is a term for chronic inflammation of the bowel that includes ulcerative colitis and Crohn diseas

Inflammatory Bowel Disease

            Inflammatory bowel disease (IBD) is a term for chronic inflammation of the bowel that includes ulcerative colitis and Crohn disease. Possible causes and risks for IBD are gene susceptibility, environmental, epithelial cell barrier function alteration, and altered immune response to intestinal microflora (Huether & McCance, 2017). The mucosal epithelium loses its ability to discern normal intestinal antigens from harmful ones and cell-mediated immunity is activated. Dendritic cells are activated, T cells differentiate, and proinflammatory cytokines and chemokines are produced (Huether & McCance, 2017). The result of the altered immune response is chronic inflammation (Centers for Disease Control and Prevention, 2018; Huether & McCance, 2017). Ulcerative colitis and Crohn disease are slightly different with location and cellular appearance. With ulcerative colitis, the cellular inflammation and destruction can lead to frequent bowel movements, pain, fever, bloody stools, fissures, and abscess. Those with Crohn disease may experience diarrhea, pain, fistulae, and obstruction (Huether & McCance, 2017).

            According to the Crohn’s and Colitis Foundation of America (2014), the onset of IBD can occur at any age, but is most common between the ages of 15 and 35. When it comes to age, Herzog et al. (2018) found that disease onset results in no change of IBD behavior or progression. Similarly, a metanalysis found that age of diagnosis does not impact mortality (Duricova, Burisch, Jess, Gower-Rousseau, & Lakatos, 2014). However, pediatric diagnosis of IBD is found to have higher rates of anemia, and stomatitis, and lower rates of arthralgia and osteopenia (Herzog et al., 2018).


            Psoriasis is a chronic and relapsing condition of the skin, scalp, and nails. Psoriasis appears to be T cell driven. Dendritic cells react to a trigger and secrete cytokines (Fischer, 2017). Interleukins are secreted, impacting keratinocyte proliferation, cytokine secretion, and more activation of T cells (Fischer, 2017). Psoriasis is marked by a thickening of the dermis and epidermis because of cellular hyperproliferation, altered keratinocyte differentiation, and expanded dermal vasculature, causing scales and thickened red plaques (Huether & McCance, 2017). Psoriasis can occur at any age, although generally happens by the age of 35. There is not a lot of information on the factor of age. Gulliver, Parfre, Gulliver, Randell, and Connors (2016) state that psoriasis is associated with excess cardiovascular-related deaths and decreased longevity of 20 years. The authors state there are no predictive factors for at risk patients (Gulliver et al., 2016).

Comparison of IBD and Psoriasis

            IBD and psoriasis seem to be the result of altered innate and cell-mediated response. Both have a cellular-mediated immune response that result in a chronic inflammatory response. In both conditions, dendritic cells are activated, T cells are mobilized, and eventually inflammatory mediators are released. Patients who suffer experience both periods of remission and exacerbation or flares. However, their locations and clinical manifestations are very different. Psoriasis causes the over-proliferation of the dermis and epidermis. IBD is marked by damage and inflammation to the mucosa and submucosa.


Centers for Disease Control and Prevention. (2018). What is inflammatory bowel disease (IBD)?

Retrieved from

Crohn’s and Colitis Foundation of America (2014). The facts about inflammatory bowel

diseases. Retrieved from

Duricova, D., Burisch, J., Jess, T., Gower-Rousseau, G., & Lakatos, P. (2014). Age-related

            differences in presentation and course of inflammatory bowel disease: An update on the

            population-based literature. Journal of Crohn’s and Colitis, 8(11), 1351-1361. doi:

Fischer, S. (2017). 2017 update: Etiology and pathogenesis of psoriasis. Retrieved from

Gulliver, W., Parfre, B., Gulliver, S., Randell, S., & Connors, S. (2016). Early age of onset of

            psoriasis (<25 years of age) may be a predictor for cardiovascular disease in patients with

            severe psoriasis. Journal of the American Academy of Dermatology, 74(5), AB244. doi:

Herzog, D., Fournier, N., Buehr, P., Rueter, V., Koller, R., Helyand, K., Nydegger, A.,

Spalinger, J., Schibli, S., Petit, L., & Braegger, C. (2018). Age at disease onset of inflammatory bowel disease is associated with later extraintestinal manifestations and complications. European Journal of Gastroenterology & Hepatology, 30(6), 598-607. doi: 10.1097/MEG.0000000000001072

Huether, S.E., & McCance, K.L. (2017). Understanding pathophysiology (6th ed.). St. Louis,

            MO: Mosby. 


Bottom of Form


Get 20% Discount on This Paper
Pages (550 words)
Approximate price: -

Try it now!

Get 20% Discount on This Paper

We'll send you the first draft for approval by at
Total price:

How it works?

Follow these simple steps to get your paper done

Place your order

Fill in the order form and provide all details of your assignment.

Proceed with the payment

Choose the payment system that suits you most.

Receive the final file

Once your paper is ready, we will email it to you.

Our Services

Ace Writing Center has stood as the world’s leading custom essay writing services providers. Once you enter all the details in the order form under the place order button, the rest is up to us.


Essay Writing Services

At Ace Writing Center, Nowadays, students normally have extremely busy schedules. You will note that some of them have to take on some evening or weekend jobs in order to get some income that can help them to sustain in college or in the university. This can deny them a chance to write all the essays given. Others usually get bombarded with a lot of work by their lecturers. This can still delay such students from working on all their essays. However, some of them usually try to work on all these essays but end up delivering their work late. This can prevent them from graduating since most lecturers are strict on deadlines. If you want to write a business essay, the wise way is to hire an outstanding essay writing service like us, so that you can get the best results. If you are keen, you will note that many companies usually overcharge their customers. Some of them are there only to make money. And in reality, they really don’t care to build a long term commitment with students. You should not choose such companies. You should take your time and choose a reliable company to work with. Ace Writing Center is the ultimate solution for you. We have been offering our writing service for more than 7 years. This is a clear indication that you will get quality essay writing service. We have a wide range of writers who can work on any business essay that you might have. We believe in doing extensive research so that we can provide quality work to all our clients. .


Admission and Business Papers

Have you ever had to write an admission essay for college? The majority of students face the same issues when applying to a university or college and many in such situations decide they need professional help to cope with this matter. They get in a situation when the deadline keeps coming closer but lack motivation to start because they are just not sure if their writing skills are strong enough. We have a solution for you! Ace Writing Center is the best admission essay writing service with a large professional team and years of experience in providing high-quality papers to students of all levels and faculties. The mission of our team is to help students make their dreams of entering a good college come true and that’s what we offer!.


Editing and Proofreading

Sometimes all the words for your paper just flow out of your mind and into your fingers. You type quickly at your keyboard and there they are, your beautiful words right there on the screen. But you have no idea how to polish it up. You may be wishing there was a paper writing service that offered this type of writing service. Look no more! Here at Ace Writing Center, we offer you an editing and proofreading option that you can't find anywhere else..


College Essay Writing

In case you are familiar Ace Writing Center, you know the way to distinguish a better company from a cheap one exactly. First of all, poor service website does not have a sufficient support. We think support team is an essential part of success; it has to answer all clients’ questions and be a connecting link between clients and their writers. On our web-service you will get answers about anything you need and your writer will receive all your instructions, assignments and requirements exactly and swiftly. A writing service that we run has got a flexible pricing system that will save you from senseless wastes and many bonus systems that let you sparing money for something important for you.

Open chat
Hello. Can we help you?