Respond on two different days who selected different treatments and factors than you, in the following ways:
Offer alternative common treatments for the disorders.
Share insight on how the factor you selected impacts the treatment of alterations of digestive function.
Main Post
Many patients will present with disease processes that have the same or similar symptoms, and it will be the responsibility of the practitioner to diagnose and provide treatment accurately. The gastrointestinal tract is one area where misdiagnoses occur due to the common signs and symptoms. Inflammatory bowel disease and irritable bowel syndrome are two common misdiagnosed disorders that will be explored, the pathophysiology explained, proper treatment, and the effects gender has on these diseases.
Pathophysiology of Inflammatory Bowel Disease and Irritable Bowel Syndrome
Inflammatory bowel disease (IBD) comprises three key disorders; Crohn’s disease (CD), ulcerative colitis (UC), and microscopic colitis all attributed to an inflammation process but each affects the body differently. Research by El-Salhy and Hausken (2016) explains that the inflammation in Crohn’s disease is transmural in nature and occurs in any part of the gastrointestinal tract, while the inflammation in ulcerative colitis is more superficial and affects the rectocolonic mucosa, and the inflammation in microscopic manifests as mucosal and submucosal infiltration of immune cells without ulcerations or crypt abscesses and occurs in the colon.
Irritable bowel syndrome (IBS) is a common disease, although the pathophysiology is still not fully understood. Combination of low-grade mucosal inflammation with visceral hypersensitivity and impaired bowel motility could be the underlying etiology for IBS pathogenesis (Chong et al., 2019). Alterations in the gut microbiota and dietary choices play a central role in disease development. According to O’Malley (2019), IBS is complex multifactorial pathophysiology, that involves dysfunction of the bi-directional signaling axis between the brain and the gut, this axis incorporates efferent and afferent branches of the autonomic nervous system, circulating endocrine hormones and immune factors, local paracrine and neurocrine factors and microbial metabolites.
Treatments for Inflammatory Bowel Disease and Irritable Bowel Syndrome
Treatment for IBS and IBD focuses on treating not only the symptoms but the underlying cause of the disease. Treatment for IBS includes; dietary interventions, probiotics, prebiotics, synbiotics, non-absorbable antibiotics, mixed μ-opioid receptor agonist–δ-opioid receptor antagonist and κ-opioid receptor agonist, Serum-derived bovine immunoglobulin (SBI), and fecal microbiota transplantation (FMT). Treatment for IBD is more complex due to IBD being composed of three different diseases, each requires different treatment plans, but there is some crossover. Corticosteroids, probiotics, immunomodulatory drugs, immunosuppressants, antitumor necrosis factor therapy, anti-interleukin 12/23 antibody drugs, janus kinase (JAK) inhibitor, SMAD 7 inhibitor, and FMT are treatments available for IBD. 5-aminosalicylates (5-ASAs) are the first-line therapy for induction and maintenance of remission in patients with UC (Su et al., 2019). Anti-tumor necrosis factor (TNF) therapy works well on both UC and CD, JAK inhibitor works for UC and not CD, SMAD 7 inhibitor works for CD but not UC.
Gender’s Affect on Inflammatory Bowel Disease and Irritable Bowel Syndrome
Research conducted by Kosako, Akiho, Miwa, Kanazawa, and Fukudo (2018) acknowledges that the higher prevalence of IBS in women compared with men may be associated with sex hormone fluctuations, which reportedly affect IBS symptoms, with symptoms appearing stronger before menstruation. Women may also receive a delay in treatment to both IBD and IBS due to the perceived perception of pain being misdiagnosed by the primary care practitioner.
Conclusion
The gastrointestinal tract has many disorders where the signs and symptoms are the same. It is imperative that the practitioner distinguishes between diseases as the therapies can become complicated. The practitioner must do a comprehensive physical exam, as well as a health history with the patient to determine the path towards diagnosis. Laboratory data and imaging can also play a key role in determining the proper treatment plan and diagnosis. Unsuccessful medical treatment will warrant more invasive procedures in an attempt to visualize the underlying issue.
References
Chong, P. P., Chin, V. K., Looi, C. Y., Wong, W. F., Madhavan, P., & Yong, V. C. (2019). The Microbiome and Irritable Bowel Syndrome–A Review on the Pathophysiology, Current Research and Future Therapy. Frontiers in Microbiology, 10, 1136.. https://doi-org.ezp.waldenulibrary.org/10.3389/fmicb.2019.01136
El-Salhy, M., & Hausken, T. (2016). The role of the neuropeptide Y (NPY) family in the pathophysiology of inflammatory bowel disease (IBD). Neuropeptides, 55, 137–144. https://doi-org.ezp.waldenulibrary.org/10.1016/j.npep.2015.09.005
Kosako, M., Akiho, H., Miwa, H., Kanazawa, M., & Fukudo, S. (2018). Impact of symptoms by gender and age in Japanese subjects with irritable bowel syndrome with constipation (IBS-C): A large population-based internet survey. BioPsychoSocial Medicine, 12(1). https://doi-org.ezp.waldenulibrary.org/10.1186/s13030-018-0131-2
O’Malley, D. (2019). Endocrine regulation of gut function – a role for glucagon‐like peptide‐1 in the pathophysiology of irritable bowel syndrome. Experimental Physiology, 104(1), 3–10. https://doi-org.ezp.waldenulibrary.org/10.1113/EP087443
Su, H.-J., Chiu, Y.-T., Chiu, C.-T., Lin, Y.-C., Wang, C.-Y., Hsieh, J.-Y., & Wei, S.-C. (2019). Inflammatory bowel disease and its treatment in 2018: Global and Taiwanese status updates. Journal of the Formosan Medical Association, 118(7), 1083–1092. https://doi-org.ezp.waldenulibrary.org/10.1016/j.jfma.2018.07.005Many patients will present with disease processes that have the same or similar symptoms, and it will be the responsibility of the practitioner to diagnose and provide treatment accurately. The gastrointestinal tract is one area where misdiagnoses occur due to the common signs and symptoms. Inflammatory bowel disease and irritable bowel syndrome are two common misdiagnosed disorders that will be explored, the pathophysiology explained, proper treatment, and the effects gender has on these diseases.
Pathophysiology of Inflammatory Bowel Disease and Irritable Bowel Syndrome
Inflammatory bowel disease (IBD) comprises three key disorders; Crohn’s disease (CD), ulcerative colitis (UC), and microscopic colitis all attributed to an inflammation process but each affects the body differently. Research by El-Salhy and Hausken (2016) explains that the inflammation in Crohn’s disease is transmural in nature and occurs in any part of the gastrointestinal tract, while the inflammation in ulcerative colitis is more superficial and affects the rectocolonic mucosa, and the inflammation in microscopic manifests as mucosal and submucosal infiltration of immune cells without ulcerations or crypt abscesses and occurs in the colon.
Irritable bowel syndrome (IBS) is a common disease, although the pathophysiology is still not fully understood. Combination of low-grade mucosal inflammation with visceral hypersensitivity and impaired bowel motility could be the underlying etiology for IBS pathogenesis (Chong et al., 2019). Alterations in the gut microbiota and dietary choices play a central role in disease development. According to O’Malley (2019), IBS is complex multifactorial pathophysiology, that involves dysfunction of the bi-directional signaling axis between the brain and the gut, this axis incorporates efferent and afferent branches of the autonomic nervous system, circulating endocrine hormones and immune factors, local paracrine and neurocrine factors and microbial metabolites.
Treatments for Inflammatory Bowel Disease and Irritable Bowel Syndrome
Treatment for IBS and IBD focuses on treating not only the symptoms but the underlying cause of the disease. Treatment for IBS includes; dietary interventions, probiotics, prebiotics, synbiotics, non-absorbable antibiotics, mixed μ-opioid receptor agonist–δ-opioid receptor antagonist and κ-opioid receptor agonist, Serum-derived bovine immunoglobulin (SBI), and fecal microbiota transplantation (FMT). Treatment for IBD is more complex due to IBD being composed of three different diseases, each requires different treatment plans, but there is some crossover. Corticosteroids, probiotics, immunomodulatory drugs, immunosuppressants, antitumor necrosis factor therapy, anti-interleukin 12/23 antibody drugs, janus kinase (JAK) inhibitor, SMAD 7 inhibitor, and FMT are treatments available for IBD. 5-aminosalicylates (5-ASAs) are the first-line therapy for induction and maintenance of remission in patients with UC (Su et al., 2019). Anti-tumor necrosis factor (TNF) therapy works well on both UC and CD, JAK inhibitor works for UC and not CD, SMAD 7 inhibitor works for CD but not UC.
Gender’s Affect on Inflammatory Bowel Disease and Irritable Bowel Syndrome
Research conducted by Kosako, Akiho, Miwa, Kanazawa, and Fukudo (2018) acknowledges that the higher prevalence of IBS in women compared with men may be associated with sex hormone fluctuations, which reportedly affect IBS symptoms, with symptoms appearing stronger before menstruation. Women may also receive a delay in treatment to both IBD and IBS due to the perceived perception of pain being misdiagnosed by the primary care practitioner.
Conclusion
The gastrointestinal tract has many disorders where the signs and symptoms are the same. It is imperative that the practitioner distinguishes between diseases as the therapies can become complicated. The practitioner must do a comprehensive physical exam, as well as a health history with the patient to determine the path towards diagnosis. Laboratory data and imaging can also play a key role in determining the proper treatment plan and diagnosis. Unsuccessful medical treatment will warrant more invasive procedures in an attempt to visualize the underlying issue.
References
Chong, P. P., Chin, V. K., Looi, C. Y., Wong, W. F., Madhavan, P., & Yong, V. C. (2019). The Microbiome and Irritable Bowel Syndrome–A Review on the Pathophysiology, Current Research and Future Therapy. Frontiers in Microbiology, 10, 1136.. https://doi-org.ezp.waldenulibrary.org/10.3389/fmicb.2019.01136
El-Salhy, M., & Hausken, T. (2016). The role of the neuropeptide Y (NPY) family in the pathophysiology of inflammatory bowel disease (IBD). Neuropeptides, 55, 137–144. https://doi-org.ezp.waldenulibrary.org/10.1016/j.npep.2015.09.005
Kosako, M., Akiho, H., Miwa, H., Kanazawa, M., & Fukudo, S. (2018). Impact of symptoms by gender and age in Japanese subjects with irritable bowel syndrome with constipation (IBS-C): A large population-based internet survey. BioPsychoSocial Medicine, 12(1). https://doi-org.ezp.waldenulibrary.org/10.1186/s13030-018-0131-2
O’Malley, D. (2019). Endocrine regulation of gut function – a role for glucagon‐like peptide‐1 in the pathophysiology of irritable bowel syndrome. Experimental Physiology, 104(1), 3–10. https://doi-org.ezp.waldenulibrary.org/10.1113/EP087443
Su, H.-J., Chiu, Y.-T., Chiu, C.-T., Lin, Y.-C., Wang, C.-Y., Hsieh, J.-Y., & Wei, S.-C. (2019). Inflammatory bowel disease and its treatment in 2018: Global and Taiwanese status updates. Journal of the Formosan Medical Association, 118(7), 1083–1092. https://doi-org.ezp.waldenulibrary.org/10.1016/j.jfma.2018.07.005
Try it now!
How it works?
Follow these simple steps to get your paper done
Place your order
Fill in the order form and provide all details of your assignment.
Proceed with the payment
Choose the payment system that suits you most.
Receive the final file
Once your paper is ready, we will email it to you.
Our Services
Ace Writing Center has stood as the world’s leading custom essay writing services providers. Once you enter all the details in the order form under the place order button, the rest is up to us.
Essays
At Ace Writing Center, Nowadays, students normally have extremely busy schedules. You will note that some of them have to take on some evening or weekend jobs in order to get some income that can help them to sustain in college or in the university. This can deny them a chance to write all the essays given. Others usually get bombarded with a lot of work by their lecturers. This can still delay such students from working on all their essays. However, some of them usually try to work on all these essays but end up delivering their work late. This can prevent them from graduating since most lecturers are strict on deadlines. If you want to write a business essay, the wise way is to hire an outstanding essay writing service like us, so that you can get the best results. If you are keen, you will note that many companies usually overcharge their customers. Some of them are there only to make money. And in reality, they really don’t care to build a long term commitment with students. You should not choose such companies. You should take your time and choose a reliable company to work with. Ace Writing Center is the ultimate solution for you. We have been offering our writing service for more than 7 years. This is a clear indication that you will get quality essay writing service. We have a wide range of writers who can work on any business essay that you might have. We believe in doing extensive research so that we can provide quality work to all our clients. .
Admissions
Admission and Business Papers
Have you ever had to write an admission essay for college? The majority of students face the same issues when applying to a university or college and many in such situations decide they need professional help to cope with this matter. They get in a situation when the deadline keeps coming closer but lack motivation to start because they are just not sure if their writing skills are strong enough. We have a solution for you! Ace Writing Center is the best admission essay writing service with a large professional team and years of experience in providing high-quality papers to students of all levels and faculties. The mission of our team is to help students make their dreams of entering a good college come true and that’s what we offer!.
Editing
Editing and Proofreading
Sometimes all the words for your paper just flow out of your mind and into your fingers. You type quickly at your keyboard and there they are, your beautiful words right there on the screen. But you have no idea how to polish it up. You may be wishing there was a paper writing service that offered this type of writing service. Look no more! Here at Ace Writing Center, we offer you an editing and proofreading option that you can't find anywhere else..
Coursework
College Essay Writing
In case you are familiar Ace Writing Center, you know the way to distinguish a better company from a cheap one exactly. First of all, poor service website does not have a sufficient support. We think support team is an essential part of success; it has to answer all clients’ questions and be a connecting link between clients and their writers. On our web-service you will get answers about anything you need and your writer will receive all your instructions, assignments and requirements exactly and swiftly. A writing service that we run has got a flexible pricing system that will save you from senseless wastes and many bonus systems that let you sparing money for something important for you.
